BRI is actively engaged in biotechnology-related research and development projects, which focus primarily on neuroscience, TCM-based drug discovery, and lead identification and optimization.
Neuroscience
Our research programs in neuroscience relate to the unraveling of the complex processes involved in the pathology of neurodegenerative diseases. By understanding the mechanisms involved in the progression of these diseases, BRI aims to identify novel molecular targets associated with defective and impaired neurotransmission, and to develop therapeutic agents for the treatment of neurological diseases.
TCM-based Drug Discovery
TCM has been successfully used in Chinese culture for thousands of years in the treatment of diseases. We utilize modern technology to provide scientific verification of the efficacy and safety of TCM, and aim to identify biologically active compounds that can be further developed into new promising therapeutic agents.
Drug Lead Identification and Optimization
We use multiple approaches, including genetic engineering, nuclear magnetic resonance (NMR) and computer-aided drug design, to elucidate the structure and function of biological macromolecules, as well as the structural basis of their interactions with lead compounds. Such information is instrumental to target selection and lead identification and can be further utilized in the design of potential lead compounds.